STATEMENT OF NEED

Despite major therapeutic advances in the treatment of newly diagnosed multiple myeloma (NDMM), frontline management remains highly complex, creating an urgent need for practical, case-based education. While newer anti-CD38–based quadruplet regimens achieve deeper responses and higher measurable residual disease (MRD) negativity rates than standard triplets, clinicians often struggle with regimen selection—particularly for frail, elderly, or high-risk patients where balancing efficacy with tolerability is critical. Furthermore, the evolving role of upfront stem cell transplantation and the practical, real-world application of MRD to guide maintenance therapy and treatment duration present ongoing clinical challenges (NCCN, 2026). To bridge these practice gaps, an expert multidisciplinary panel featuring hematologist-oncologist Dr. Rahul Banerjee, clinical pharmacist Dr. Ashley Chen, and nurse practitioner Dr. Beth Faiman will lead a CME/NCPD/CPE-accredited virtual rounds centered on sequential, real-world patient scenarios. By completing this interactive activity, oncology clinicians, pharmacists, and nurses will gain actionable, evidence-based decision frameworks to confidently navigate triplet versus quadruplet therapies, optimize adverse event management, and utilize MRD assessments to deliver highly personalized, high-quality care for diverse NDMM patient populations.

TARGET AUDIENCE

Community and academic hematologists-oncologists, medical oncologists, advanced practice providers, oncology nurses, oncology pharmacists, and other HCPs involved in the management of patients with multiple myeloma (MM).

LEARNING OBJECTIVES

Upon completion of this activity, participants should be able to:

• Differentiate triplet and quadruplet regimens for transplant-eligible and transplant-ineligible patients with NDMM based upon efficacy, safety, and patient-specific factors

• Apply the latest evidence to individualize frontline therapy selection and drug dosing for elderly, high-risk, and frail patients with NDMM using risk-adapted strategies

• Integrate MRD assessment into clinical decision making to optimize treatment duration, maintenance therapy selection, and treatment intensification in patients with NDMM

 REGISTRATION

JOINTLY ACCREDITED PROVIDER

In support of improving patient care, i3 Health is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

PHYSICIANS

i3 Health designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 Medical Knowledge MOC point in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

By providing this information, participants are agreeing to allow i3 Health to share this information with the ACCME.

Physician Assistants/Associates

i3 Health has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.0 AAPA Category 1 CME credit. Approval is valid until 7/28/26. PAs should only claim credit commensurate with the extent of their participation.

Nurse Practitioners

The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. Individuals are responsible for checking with the AANPCP for further guidelines.

Nursing Continuing Professional Development 

A maximum of 1.0 ANCC contact hour may be earned by learners who successfully complete this nursing continuing professional development activity. This activity has been designated for TBD ANCC contact hours of pharmacology credit for Advanced Practice Registered Nurses.

Provider approved by the California Board of Registered Nursing, Provider Number 15824, for 1.0 ANCC contact hour. 

Continuing Pharmacy Education

i3 Health has approved this knowledge-based activity for 1.0 ACPE CE hour. The Universal Activity Number for this activity is TBD. Pharmacy CE credits can be submitted to the NABP upon successful completion of the activity and the evaluation by providing your NABP ID and DOB, which must be submitted within 60 days of completion. 

DISCLOSURE OF RELEVANT FINANCIAL INFORMATION WITH INELIGIBLE COMPANIES

i3 Health endorses the standards of the ACCME, ANCC, and ACPE that require everyone in a position to control the content of a CME/NCPD/CPE activity to disclose all financial relationships with ineligible companies that are related to the content of the CME/NCPD/CPE activity. CME/NCPD/CPE activities must be balanced, independent of commercial bias, and promote improvements or quality in healthcare. All recommendations involving clinical medicine must be based on evidence accepted within the medical profession.

A conflict of interest is created when an individual has an opportunity to affect CME/NCPD/CPE content about products or services of an ineligible company with which he/she has a financial relationship, which therefore may bias their opinions and teaching. This may include receiving a salary, royalty, intellectual property rights, consulting fee, honoraria, stocks, or other financial benefits.

i3 Health will identify, review, and mitigate all relevant financial relationships that speakers, authors, or planners disclose prior to an educational activity being delivered to learners. Disclosure of a relationship is not intended to suggest or condone bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation. i3 Health does not endorse any products or services.

Relevant financial relationships exist between the following individuals and ineligible companies:

Rahul Banerjee, MD, FACP, discloses that he has served as a consultant for Adaptive Biotech, Arcellx, Bristol Myers Squibb, Caribou, Genentech/Roche, Gilead/Kite, GSK, Karyopharm, Legend Biotech, Johnson & Johnson, Pfizer, Poseida, Sanofi Pasteur, and SparkCures; and that he has received grants/research support from AbbVie, Bristol Myers Squibb, Johnson & Johnson, Karyopharm, Novartis, Pack Health, Prothena, and Sanofi.

Ashley Chen, PharmD, BCOP, has no relevant financial relationships to disclose.

Beth Faiman, PhD, MSN, APN-BC, AOCN®, BMTCN®, FAAN, FAPO, discloses that she has has served as a consultant for GSK, Janssen, and Sanofi. 

The i3 Health planners, reviewers, and managers have nothing to disclose.

i3 Health has mitigated all relevant financial relationships.

INSTRUCTIONS TO RECEIVE CREDIT

In order to receive credit for this activity, participants must submit a completed evaluation at the end of the activity.

TECHNOLOGY REQUIREMENTS FOR VIRTUAL CME | NCPD | CPE ACTIVITIES

For virtual (asynchronous, archived live, home study; synchronous webinars) CME/NCPD/CPE activities, include access to system requirements:

• The Internet browser(s) supported and minimum versions of each required by the learner to complete the online activity.

• The minimum memory, storage, processor, and Internet speeds require by the learner to complete the online activity.

UNAPPROVED USE DISCLOSURE

i3 Health requires CME/NCPD/CPE faculty (speakers) to disclose to attendees when products or procedures being discussed are off-label, unlabeled, experimental, and/or investigational (not FDA approved), as well as any limitations on the information that is presented, such as data that are preliminary or that represent ongoing research, interim analyses, and/or unsupported opinion. Faculty may discuss information about pharmaceutical agents that is outside of U.S. Food and Drug Administration approved labeling.

This information is intended solely for continuing medical education and is not intended to promote off-label use of these medications. If you have questions, contact the medical affairs department of the manufacturer for the most recent prescribing information.

DISCLAIMER

The information provided at this CME/NCPD/CPE activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

COMMERCIAL SUPPORT

This activity is supported by independent educational grants from Johnson & Johnson and Sanofi.

Aggregate participant data will be shared with commercial supporters of this activity.

CONTACT INFORMATION

Technical queries or questions regarding activity credit should be directed to i3 Health at support@i3health.com.